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产品信息
应用 | 建议稀释比 |
免疫印迹 (WB) | 1:500-1:2,000 |
免疫组织化学（多聚甲醛固定） (IHC (PFA)) | 1:50-1:200 |
免疫细胞化学 (ICC/IF) | 1:100-1:500 |
产品规格 | |
种属反应 | Human, Mouse, Rat |
宿主/亚型 | Rabbit / IgG |
分类 | Polyclonal |
类型 | Antibody |
抗原 | A synthesized peptide derived from human TDGF1(Accession P13385), corresponding to amino acid residues H108-C131. |
偶联物 | Unconjugated |
形式 | Liquid |
浓度 | 1 mg/mL |
纯化类型 | Affinity chromatography |
保存液 | PBS with 50% glycerol, 150mM NaCl |
内含物 | 0.02% sodium azide |
保存条件 | -20°C |
靶标信息
Cripto-1 (TDGF1) is a GPI-anchored cell membrane proetin involved in Nodal signaling. Cell associated TDGF1 acts as a a Nodeal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulated Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. TDGF1 is expressed both in ES cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers
